The Lab of Physio-Genomics
-Publications-

for a up-to-date Google Scholar listing go to https://scholar.google.com/

Selected Publications

Metabolism & Genomics Research

• • Son JE*, Dou Z, Wanggou S, Chan J, Mo R, Li X, Huang X, Kim KH, Michaud J, Hui CC*. Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency. (2021) Science Advances, 7(44):eabh4503 (*, co-correspondence) (IF: 13.6)

  • Son JE*, Dou Z*, Kim KH, Wanggou S, Cha VSB, Mo R, Zhang X, Ketela T, Chen X, Li X, Huang X, Hui CC. Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response. (2021) Nature Metabolism, 3(5):701-713 (*, Equal contribution) (IF: 20.8)
        -Highlighted in the "Focus on neural control of energy homeostasis", Nature Metabolism

  • Kim KH*, Kim YH*, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SMI, Doh KO, Hui CC, Sung HK. Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. (2017) Cell Research, 27(11):1309-1326 (IF: 44.1)

  • Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. Obesity-associated variants within FTO form long-range functional connections with IRX3. (2014) Nature, 507(7492):371-5 (IF: 64.8)

  • Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SM, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson T, Nagy A. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. (2013) Cell Metabolism, 8;17(1):61-72 (IF: 29.0)

Food/Nutrients Research

• • Son JE*, Jo J.-Y*, Kim S, Park MJ, Lee Y, Park SS, Park SY, Jung SM, Jung SK, Kim JY and Byun S.  Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling. (2023) Nutrients, 15(16), 3630, (*, Equal contribution) (IF: 5.9)

  • Kim JE*, Son JE*, Jeong H, Kim DJ, Seo SK, Lee E, Lim TG, Kim JR, Chen H, Bode AM, Lee KW, Dong Z. A novel cinnamon-related natural product with Pim-1 inhibitory activity inhibits leukemia and skin cancer. (2015) Cancer Research,75(13):2716-2728 (*, Equal contribution) (IF: 11.2)

  • Son JE, Lee E, Jung SK, Kim JE, Oak MH, Lee KW, Lee HJ. Anthocyanidins, novel FAK inhibitors, attenuate PDGF-BB-induced aortic smooth muscle cell migration and neointima formation. (2014) Cardiovascular Research, 101(3):503-12 (IF: 10.9)

  • Son JE, Hwang MK, Lee E, Seo SG, Kim JE, Jung SK, Kim JR, Ahn GH, Lee KW, Lee HJ. Persimmon peel extract attenuates PDGF-BB induced migration and invasion in human aortic smooth muscle cells by inhibition of Src kinase activity. (2013) Food chemistry, 141(4):3309-16 (IF: 8.8)

All Publications

1. Li YZ, Son JE, Lee JH, Rapps J, Pollock-Tahiri E, Ghebreselassie M, Chen C, Premsigh BP, Bazinet R, Billia P, Hui CC, Sung HK, Yoo P and Woo M. Vagal Insulin Signaling Determines Peripheral Insulin Resistance and Inflammatory State. Nature Communications (Under Review)

2. Yun S, Noh M, Yu J, Kim HJ, Hui CC, Lee H, Son JE. Unlocking biological mechanisms with integrative functional genomics approaches. (2024) Molecules and Cells. 47(8):100092

3. Son JE. Genetics, Pharmacotherapy, and Dietary Interventions in Childhood Obesity. (2024) Journal of Pharmacy & Pharmaceutical Sciences, 27:12861 

4. Son JE*, Jo J.-Y*, Kim S, Park MJ, Lee Y, Park SS, Park SY, Jung SM, Jung SK, Kim JY and Byun S.  Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling. (2023) Nutrients, 15(16), 3630, (*, Equal contribution)

5. Kim DH, Jeong M, Kim JH, Son JE, Lee JJY, Park SJ, Lee J, Kim M, Oh JW, Park MS, and Byun S. Lactobacillus salivarius HHuMin-U activates innate immune defense against norovirus infection through TBK1-IRF3 and NF-κB signaling pathways. (2022) Research, 2022;0007

6. Chen X, Momin A, Wanggou S, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JF, Talipova K, Chen YX, Veerasammy K, Fekete A, Kumar SA, Xiong X, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan L, Zhang J, Ramaswamy V, Selvadurai H, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X, Huang X. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. (2022) Neuron, 111(1):30-48

7. Son JE, Dou Z, Kim KH, Hui CC. Deficiency of Irx5 protects mice from diet-induced obesity and associated metabolic abnormalities. (2022) International Journal of Obesity, 46(11):2029-2039

8. Jo S, Samarpita S, Lee JS, Lee YJ, Son JE, Jeong M, Kim JH, Hong S, Yoo SA, Kim WU, Rasool M, Byun S.   8-Shogaol inhibits rheumatoid arthritis through targeting TAK1. (2022) Pharmacological Research, 178:106176

9. Dou Z, Son JE*, Hui CC*. Irx3 and Irx5 - novel regulatory factors of postnatal hypothalamic neurogenesis. (2021) Frontiers in Neuroscience, 15:763856. (*, co-correspondence)

10. Son JE*, Dou Z, Wanggou S, Chan J, Mo R, Li X, Huang X, Kim KH, Michaud J, Hui CC*. Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency. (2021) Science Advances, 7(44):eabh4503 (*, co-correspondence)

11. Son JE*, Dou Z*, Kim KH, Wanggou S, Cha VSB, Mo R, Zhang X, Ketela T, Chen X, Li X, Huang X, Hui CC. Irx3 and Irx5in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response. (2021) Nature Metabolism, 3(5):701-713, (*, Equal contribution) 

12. Kim MJ, Febbraro D, Farkona S, Gillmore T, Son JE, Regeenes R, Chang HH, Pollock-Tahiri E, Yang J, Park YJ, Sivasubramaniyam T, Oh SJ, Saraon P, Stagljar I, Rocheleau JV, Hui CC, Caniggia I, Hao Z, Mak TW, Konvalinka A, Woo M.Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis. (2021) Molecular Metabolism, 47:101185

13. Kim YH, Lee JH, Yeung JL, Das E, Kim RY, Jiang Y, Moon JH, Jeong H, Thakkar N, Son JE, Trzaskalski N, Hui CC, Doh KO, Mulvihill EE, Kim JR, Kim KH, Sung HK. Thermogenesis- independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice. (2019) Scientific Reports, 9(1):2479 

14. Yin WC, Satkunendran T, Mo R, Morrissy S, Zhang X, Huang ES, Uusküla-Reimand L, Hou H, Son JE, Liu W, Liu YC, Zhang J, Parker J, Wang X, Farooq H, Selvadurai H, Chen X, Sau-Wai Ngan E, Cheng SY, Dirks PB, Angers S, Wilson MD, Taylor MD, Hui CC. Dual regulatory functions of SUFU and targetome of GLI2 in SHH subgroup medulloblastoma. (2019) Developmental Cell, 48(2):167-183

15. Kim HJ*, Son JE*, Kim JH*, Lee CC, Yang H, Yaghmoor SS, Ahmed Y, Yousef JM, Abualnaja KO, Al-Malki AL, Kumosani TA, Park JHY, Lee CY, Kim JE, Lee KW. Gingerenone A attenuates monocyte-endothelial adhesion via suppression of I Kappa B kinase phosphorylation. (2018) Journal of Cellular Biochemistry, 119(1):260-268 (*, Equal contribution)

16. Kim KH*, Kim YH*, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SMI, Doh KO, Hui CC, Sung HK. Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. (2017) Cell Research, 27(11):1309-1326

17. Jeong H, Kim JH, Lee E, Jang YJ, Son JE, Kwon JY, Lim TG, Kim S, Park JH, Kim JE, Lee KW. Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. (2016) Oncotarget, 7(41):67223-67234

18. Huh WB, Kim JE, Kang YG, Park G, Lim TG, Kwon JY, Song DS, Jeong EH, Lee CC, Son JE, Seo SG, Lee E, Kim JR, Lee CY, Park JS, Lee KW. Brown pine leaf extract and its active component trans-communic acid inhibit UVB-induced MMP-1 expression by targeting PI3K. (2015) Plos One, 10(6)

19. Kim JE*, Son JE*, Jeong H, Kim DJ, Seo SK, Lee E, Lim TG, Kim JR, Chen H, Bode AM, Lee KW, Dong Z. A novel cinnamon-related natural product with Pim-1 inhibitory activity inhibits leukemia and skin cancer. (2015) Cancer Research,75(13):2716-2728 (*, Equal contribution)

20. Lee JH, Kim JE, Jang YJ, Lee CC, Lim TG, Jung SK, Lee E, Lim SS, Heo YS, Seo SG, Son JE, Kim JR, Lee CY, Lee HJ, Lee KW. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. (2015) Molecular Carcinogenesis, 55(5):552-62

21. Song NR, Kim JE, Park JS, Kim JR, Kang H, Lee E, Kang YG, Son JE, Seo SG, Heo YS, Lee KW. Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf. (2015) International Journal of Molecular Science, 16(3): 4453-70

22. Shin SH, Seo SG, Min S, Yang H, Lee EJ, Son JE, Kwon JY, Yue S, Chung MY, Kim KH, Cheng JX, Lee HJ, Lee KW. Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at mitotic clonal expansion stage. (2014) Journal of Agricultural and Food Chemistry, 62(19), 4306-4312

23. Son JE, Jeong H, Kim H, Kim YA, Lee E, Lee HJ, Lee KW. Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cells proliferation and migration by direct inhibition of FAK. (2014) Biochemical Pharmacology, 89(2):236-45

24. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. Obesity-associated variants within FTO form long-range functional connections with IRX3. (2014) Nature, 507(7492):371-5

25. Son JE, Lee E, Jung SK, Kim JE, Oak MH, Lee KW, Lee HJ. Anthocyanidins, novel FAK inhibitors, attenuate PDGF-BB-induced aortic smooth muscle cell migration and neointima formation. (2014) Cardiovascular Research, 101(3):503-12

26. Son JE, Lee E, Seo SG, Lee J, Kim JE, Kim J, Lee KW, Lee HJ. Eupatilin, a major flavonoid of Artemisia, attenuates aortic smooth muscle cell proliferation and migration by inhibiting PI3K, MKK3/6 and MKK4 activity. (2013) Planta Medica, 79(12):1009-16

27. Son JE, Hwang MK, Lee E, Seo SG, Kim JE, Jung SK, Kim JR, Ahn GH, Lee KW, Lee HJ. Persimmon peel extract attenuates PDGF-BB induced migration and invasion in human aortic smooth muscle cells by inhibition of Src kinase activity. (2013) Food chemistry, 141(4):3309-16

28. Lee E, Son JE, Byun S, Lee SJ, Kim YA, Liu K, Kim J, Lim SS, Park JH, Dong Z, Lee KW, Lee HJ. CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. (2013) Toxicology and Applied Pharmacology, 272(1):12-20

29. Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SM, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson T, Nagy A. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. (2013) Cell Metabolism, 8;17(1):61-72

30. Kim HY, Jung SK, Byun S, Son JE, Oh MH, Lee J, Kang MJ, Heo YS, Lee KW, Lee HJ. Raf and PI3K are the Molecular Targets for the Anti-metastatic Effect of Luteolin. (2013) Phytotherapy Research, 27(10):1481-8 

31. Kim JE, Son JE, Jang YJ, Lee DE, Kang NJ, Jung SK, Heo YS, Lee KW, Lee HJ. Luteolin, a novel natural inhibitor of TPL2 kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression. (2011)
    Journal of Pharmacology and Experimental Therapeutics, 338(3):1013-22 

32. Kim JE, Lee DE, Lee KW, Son JE, Seo SK, Li J, Jung SK, Heo YS, Mottamal M, Bode AM, Dong Z, Lee HJ. Isorhamnetin suppresses skin cancer by inhibiting mitogen-activated protein kinase kinase 1 and phosphatidylinositol-3 kinase. (2011) Cancer Prevention Research (Phila), 4(4):582-91

33. Kim JE, Son JE, Jung SK, Kang NJ, Lee CY, Lee KW, Lee HJ. Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells. (2010) British Journal of Nutrition, 104(7):957-64

34. Kim JE, Kwon JY, Seo SK, Son JE, Jung SK, Min SY, Hwang MK, Heo YS, Lee KW, Lee HJ. Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1. (2010) Biochemical Pharmacology, 15;79(10):1473-82 

35. Choi KH, Kim JE, Song NR, Son JE, Hwang MK, Byun S, Kim JH, Lee KW, Lee HJ. Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells. (2010) Cardiovascular Research, 85 (4):836-844